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FACs sorting B-cells bound to labeled antigen
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Robust sampling of natural antibody repertoire
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Fastest timeline to sequence and screening recombinant monoclonal antibody on "FC of choice“
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Recovering vHH sequences from Immunized animals is less-complicated as compared to conventional mabs since they are derived from Homo-Dimeric BCRs rather than Hetero-Dimeric BCRs as in mice, rabbits and humans.
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Large quantities of PBMCs can be collected from Llamas and Alpacas across multiple timepoints during an immunization.